簡要描述：英文名稱： IWP-2產(chǎn)品應(yīng)用： WNT通路信號調(diào)控中國俗稱： IWP-2 抑制劑 注冊品牌： StemRD ： 美國StemRD公司訂購貨號： IWP-10規(guī)格型號： 10mg保存溫度： ﹣20℃產(chǎn)品種類： 小分子工具到貨時(shí)間： 1～5天
產(chǎn)品型號：StemRD廠商性質(zhì)：代理商更新時(shí)間：2021-11-23訪 問 量：1948產(chǎn)品目錄
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產(chǎn)品英文名稱: IWP-2
產(chǎn)品中文名稱: IWP-2
IWP-2 產(chǎn)品英文簡述:
IWP-2:N-（6-Methyl-2-benzothiazolyl）-2-[（3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl）thio]-acetamide, is a specific inhibitor of the O-acyltransferase Porcupine with IC50=27nM （Ref.）. Inhibition blocks the production of Wnt proteins that require fatty acid modifications, thus disrupting Wnt-dependent signaling. Porcupine inhibitor represent a novel class of potential therapeutics for cancer and other WNT dependent diseases.
Ref: B. Chen, et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat. Chem. Biol. 5, 100 （2009）
Purity: Greater than 99.5% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
Biological Activity: In a cell-based assay measuring the activation of the TCF reporter gene, this compound gives IC50 of 30 nM.
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